Abstract
Vascular endothclial growth fictors(VEGFs) constitute a group of structurally and functionally related growth factors that modulate many important physiological functions of endothelial cells, especially angiogenesis. This paper explain substance, which participate in signaling transduction of VEGF, including 13c1-2, caspase, focal adhesion kinasc(FAK), integrin avfl3, MAP kinase, nitric oxide(NO)and prostacyclin(PG12).
Physical therapy enhance angiogenesis for repairment of injury which as wound healing, muscle contusion, cerebrovascular disease, rheumatoid arthritis. Therefore this review assist understanding for mechanism of physical therapy as therapeutic angiogenesis.
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